Big Lez is a humanoid alien who lives in Brown Town, Australia, with his adopted son Quinton. Lez spends most of his time hanging out with his next-door neighbours Sassy and Donny, two mysterious and occasionally omniscient sasquatches, and Mike "Nolesy" Nolan, a self-employed jack of all trades. The group's activities range from casual smoke sessions to grand misadventures, eventually landing them in a bloody war against Lez's father and his army of monstrous Choomahs.